Angiogenesis, crucial for tumor growth, is heightened in CTCL [44], as it is supported by elevated levels of CXCL12-CXCR4 [45] and Ang2-Tie (Angiopoietin 2-tyrosine kinase receptor) [46] signaling during MF and SS, respectively, facilitating EC activation. The gene discussed is ANGPT2; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.