Consistent with our voltage-clamp experiments showing 6f high affinity for TASK-1, both APD50 and APD90 showed a concentration-dependent prolongation trend in the AF cohort (Figs. 9, I and J and S4, I and J), though not statistically significant at 1 μM and 12.5 μM. This evidence concerns the gene KCNK3 and atrial fibrillation.