Protein-protein interaction network analysis showed that the downregulation of Lrpprc, Hsp90a, and mTOR, GSK3β,which are all involved in regulating glucose metabolisms (22), played important role in the differential network of membrane-associated proteome under acute hyperglycemia conditions, in WT and tauKO mice, respectively (Fig. 5, G and H). Here, HSP90AA1 is linked to Hyperglycemia.