Interestingly, the membrane association of the JNK activator Map2k4 was also increased by human tau (The raw data of proteome are available at https://figshare.com/articles/dataset/human_tau_and_tau_knockout_mice_hippocampal_membrane_proteome_xlsx/27872493?file=50674347), which may explain why acute hyperglycemia triggered JNK phosphorylation in the brains of human tau–expressing mice. Here, MAPK8 is linked to Hyperglycemia.