Consistently, STZ treatment for 2 weeks also resulted in increased tau phosphorylation at Thr181, Ser422, Ser404, and Ser396 in the cortex from 3x Tg AD mice and tau phosphorylation at Thr181 and Ser296 in the cortex of WT mice (Fig. S1, G–J). Here, MAPT is linked to Alzheimer disease.