MAPT and Hyperglycemia: While consistent with previous studies, the acute hyperglycemia induced increase of tau phosphorylation at multiple residues, including Thr181, Ser202/205, and Ser422 in the cortex of both C57 and hTau mice (Fig. 1, J–L), and the phosphorylation of Thr231 in the cortex of hTau mice (Fig. 1M).