Interestingly, CD8+ Interferon-stimulated genes (ISGs+) T cells, known for their potent anti-tumor properties,16,42 emerged as primary interactors with CD4+ CXCL13+ Tfh, CD8+ CXCL13+ T, and CD8+ Temra cells in the ICB-Rs. The gene discussed is STING1; the disease is neoplasm.