,20,21 Among the various tumor-infiltrating T cell subsets, CXCL13+ T cells have emerged as a notable subset co-expressing multiple inhibitory receptors, such as programmed cell death protein 1 (PD-1), T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), lymphocyte activation gene 3 (LAG3), and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) on CD8+ T cells.16 The gene discussed is CTLA4; the disease is neoplasm.