Only with the network approach, HCN2’s gene scores in Exc_L2-3 were positively correlated with bipolar disorder PRS, and its expression in Exc_L2-3 showed positive correlations with other excitatory neuron populations but negative correlations with VIP and SST interneurons (In_VIP and In_SST; Fig. 6I). This evidence concerns the gene SST and bipolar disorder.