CD4 and neoplasm: The mean percentages of LAP+ cells in CD4+ T cells, CD8+ T cells, and granulocytes decreased on day 9 (4.2%, 7.3%, and 22.2%, respectively) compared to the percentages on day 0 before tumor inoculation (21.1%, 18.5%, and 58.2%, respectively) and the mean percentages of LAP+ cells in CD4+ T cells and CD8+ T cells increased on day 20 in unimmunized rats (23.0% and 20.1%, respectively) (Fig 3J, S6 Table).