HS3ST6 and hereditary angioedema: A variant associated with HAE-nC1INH was detected in a single German family, and it is a missense pathogenic variant in exon 2 of the HS3ST6 gene, c.430A > T; p.Thr144Ser located in chromosome 16, which encodes the HS-glucosamine 3-O-sulfotransferase 6 (3-OST-6) protein [34].