The genes associated with HAE-nC1INH include F12, the gene for coagulation factor XII (FXII); PLG, the gene for plasminogen; ANGPT1, the gene for angiopoietin-1; KNG1, the gene for kininogen-1; MYOF, the gene for myoferlin; and HS3ST6, the gene for heparan sulfate glucosamine 3-O-sulfotransferase-6 (HS3OST6). The gene discussed is PLG; the disease is hereditary angioedema.