Furthermore, acquired deficiency of plasminogen activator inhibitor 2 has been reported in HAE-nC1INH with excessive fibrinolysis [99] although it remains an open question as to whether this is a general phenomenon or a specific trait associated with certain HAE-nC1INH subpopulations [67, 100, 111, 112]. This evidence concerns the gene SERPINB2 and hereditary angioedema.