The most frequent indications for antimicrobial use were hospital acquired pneumonia (104/1000) with a median ALT of 1.68 h (IQR 0.73–3.45), fever with neutropenia (74/1000), ALT 1.07 h (IQR 0.64–3.19) and cystitis (72/1000), ALT 1.96 h (IQR 0.56–3.70). This evidence concerns the gene GPT and Decreased total neutrophil count.