And, we also analyzed differences in clinical factors (such as age, gender, clinical status, and smoked), immune marker genes (including BTK, CCL19, CXCL9, CXCR5), and cancer marker genes (such as IL17C, KRAS, S100A9, EGFR) between the two subtypes, the results showed that all clinical factors and marker genes except smoked factor in the two subtypes had significant differences (p < 0.01). Here, S100A9 is linked to cancer.