VEGFA and pulmonary hypertension: In further analyses, VEGF concentrations were significantly higher in patients with diffuse disease compared to those with localized disease (SMD = 0.30, 95% CI 0.01 to 0.59, p = 0.046), in patients with late compared to active video capillaroscopy pattern (SMD = 0.35, 95% CI 0.09 to 0.61, p = 0.008), and in patients with pulmonary hypertension compared to those without (SMD = 0.93, 95% CI 0.34 to 1.53, p = 0.002) [80].