In the iBMV cohort and the whole cohort, HER2-negative BC (HR = 2.26; 95% CI 1.34–3.84; p = 0.002) and KPS < 80% (HR = 2.60; 95% CI 1.60–4.22; p = < 0.001) were significantly associated with worse OS (Table 2). This evidence concerns the gene ERBB2 and breast cancer.