CD4 and age-related macular degeneration: In the blood samples of the AMD group, there was a significant increase in the percentage of CD25+FoxP3+ Tregs within the CD4+ T cell population, while the administration of the Rac1 inhibitor or neutralizing antibodies against TGF-β1 or IL-10 reduced the Treg percentage in the AMD mice (Figure 6C, P<0.001 and P<0.0001).