RAC1 and age-related macular degeneration: The reduction of Treg proportion was accompanied by the attenuation of TGF-β1 and IL-10 levels in the blood samples of AMD mice administered with the Rac1 inhibitor or neutralizing antibodies against TGF-β1 or IL-10 (Figure 6D, P<0.01, P<0.001, and P<0.0001).