PLEC and neoplasm: While several approaches (such as genetic manipulation [Buckup et al., 2021], PST treatment [Meier et al., 2017], or blocking peptides [Pal et al., 2017] and antibodies [Perez et al., 2021b]) decreasing the levels of functional plectin also lead to limited xenograft growth, to our knowledge, this is the first study showing that plectin inactivation prevents tumor progression in well-established preclinical mouse models.