(A) Hepatocellular carcinoma (HCC)-predisposing lesions were introduced by hydrodynamic gene delivery via tail vein injection (HDTVi) of transposon vector encoding MYC in conjunction with CRISPR/Cas9 construct targeting Tp53 (Myc;sgTp53) in Plecfl/fl and PlecΔAlb cohorts of 7-wk-old male mice. This evidence concerns the gene TP53 and hepatocellular carcinoma.