PLEC and hepatocellular carcinoma: Although HCC transcriptomes appear to differ from other cancers (Uhlen et al., 2017), our findings are in line with higher PLEC expression in other cancer entities such as oral squamous cell carcinoma (Flores et al., 2016; Yang et al., 2019), testicular cancer (Paumard-Hernández et al., 2018), or pancreatic cancer (Yin et al., 2021), and identify plectin as a specific marker for both early and advanced stages of HCC.