It is noteworthy that plectin-dependent effects on PI3K/Akt and FAK/Erk signaling were recently described for prostate cancer (Katada et al., 2012; Wenta et al., 2022) and head and neck squamous carcinoma cells (Burch et al., 2013), indicating that these observations have broader implications beyond liver cancer. This evidence concerns the gene PTK2 and prostate carcinoma.