Therefore, the most translationally impactful finding of this work is the ability of a small organoruthenium compound PST, a high-affinity plectin ligand, to effectively limit hepatocarcinogenesis in Myc;sgTp53-driven HCC mouse model as well as xenografted human HCCs, leading to the dampening of HCC burden. This evidence concerns the gene MYC and hepatocellular carcinoma.