PLEC and Familial prostate cancer: It is noteworthy that plectin-dependent effects on PI3K/Akt and FAK/Erk signaling were recently described for prostate cancer (Katada et al., 2012; Wenta et al., 2022) and head and neck squamous carcinoma cells (Burch et al., 2013), indicating that these observations have broader implications beyond liver cancer.