Indeed, plectin-dependent cytoskeletal disruption and aberrant adhesions have been previously linked to compromised migration and invasion of many non-cancerous (De Pascalis et al., 2018; Gregor et al., 2014; Marks et al., 2022; Abrahamsberg et al., 2005; Zrelski et al., 2024) as well as cancerous cell types (Buckup et al., 2021; Katada et al., 2012; McInroy and Määttä, 2011; Sutoh Yoneyama et al., 2014; Wenta et al., 2022), including HCC cells (Xu et al., 2022). Here, PLEC is linked to hepatocellular carcinoma.