PLEC and hepatocellular carcinoma: Through analysis of 1268 HCC patients, we found gene sets annotated as ‘Integrin pathway’, ‘FAK pathway’, ‘PI3K Akt/mTOR signaling’, or ‘Erk pathway’ to positively correlate with elevated plectin expression (Figure 7E; Figure 7—figure supplement 2C; Figure 7—figure supplement 3).