However, in the later stage of tumour development, TGF‐β tumour inhibition is destroyed and instead becomes a tumour‐ promoting factor, which can induce epithelial‐mesenchymal transformation (EMT), promote tumour cell invasion and metastasis, and has an immunosuppressive effect in the tumour microenvironment, and promotes angiogenesis [8]. This evidence concerns the gene TGFB1 and neoplasm.