Notably, overexpression of QKI-6-ΔKH and QKI-6-G118R mutants fails to exert significant effects on cell proliferation and migration (Fig. 4G and 4H), suggesting that the KH domain of QKI-6 is crucial for its inhibitory effects on colorectal cancer cell growth and migration. The gene discussed is RPRD1B; the disease is colorectal cancer.