Overall, this can be attributed to the inability of insulin to bind to insulin receptors or due to disruptions in the signal transduction pathway when insulin is bound and is often a consequence of obesity (Curry et al., 1982; Feldhahn et al., 1999; Mori et al., 2008; Verbrugghe et al., 2012). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.