In addition, tumor cell-highCNs closely communicated with CD8 T cells through MIF and human leukocyte antigen (HLA)-related ligand-receptor pairs, and CD8 T cell sent signals to tumor cell-highCNs via CD99–CD99 and ITGB2–ICAM1 interactions (P < .01; Fig. 6j; Fig. S16H). Here, ITGB2 is linked to neoplasm.