PDK4 and diabetes mellitus: Additionally, downregulation of PDK4 curbed the protein expression of β‐MyHc, IL‐1β, and cleaved caspase‐3 in HG/HP‐incubated cardiomyocytes, suggesting that PDK4 may be a driver for diabetes‐induced cardiac hypertrophy, apoptosis and oxidative damage (Figure 4f).