ANGPTL4 and coronary artery disorder: In our study, the association between genetically predicted inhibition of ANGPTL4 and CAD (OR = 0.44, 95% CI=0.37 to 0.53, p=6.2e-20) was significantly higher than that of LPL (OR = 0.64, 95% CI=0.61 to 0.68, p=1.4e-51), suggesting that ANGPTL4 may not only affect CAD through LPL, but also through independent pathways.