MKNK2 and cancer: It was further indicated that the tumor suppressive activity of MNK2a is due to its colocalization with p38a‐MAPK in the nucleus and thus, the alternative splicing of MKNK2 to downregulated MNK2a, which is a tumor suppressor mechanism and is lost in some types of cancers such as breast, lung, and colon carcinoma [9].