The signaling pathways enriched from the database were verified by western blot in macrophages derived from ITP patients, the results showed that YC‐4‐3 inhibited the phosphorylation of proteins in PI3K/mTOR/Akt, MAPK and NFκB/IκBα pathways (Figure 6D; Figure S7A–E, Supporting Information). The gene discussed is AKT1; the disease is autoimmune thrombocytopenic purpura.