Similar to the passive ITP mice, YC‐4‐3 significantly decreased the percentage of CD80+CD86+ M1 macrophages (Figure 5B), repressed the expression of CD64, and increased CD32B on macrophages in the spleen (Figure 5C) and bone marrow (Figure 5E). The gene discussed is CD86; the disease is autoimmune thrombocytopenic purpura.