In this study, the anomalous increased GSK‐3β+ cells in newly diagnosed ITP patients were measured, especially in M1‐like and M2‐like monocytes of patients, which can be rectified by effective HD‐DXM treatment, suggesting that GSK‐3β plays an important role in the progression of disease. The gene discussed is GSK3B; the disease is autoimmune thrombocytopenic purpura.