Importantly, AAV9-Fat-1 also conferred protection against arteriosclerosis in spontaneous (CD-fed LDLR−/− hamsters) and diet-induced (HFD-fed WT hamsters) atherosclerosis models, evidenced by reductions in plaque lesion size, lipid accumulation, and inflammatory cell infiltration in vascular walls. The gene discussed is FAT1; the disease is arteriosclerosis.