Similarly, miR-124 sensitizes CD133 (+) HCC cells to cisplatin-induced apoptosis by promoting ROS generation and c-Jun N-terminal kinase (JNK) phosphorylation, highlighting the potential of targeting the miR-124/SIRT1/ROS/JNK pathway to overcome drug resistance (Xu et al., 2019). This evidence concerns the gene SIRT1 and hepatocellular carcinoma.