In cholestasis-induced liver disease, SIRT1 activation alleviates mitochondrial dysfunction, reduces apoptosis, and suppresses oxidative stress, all of which contribute to fibrosis and liver aging (Yang et al., 2019; Yu et al., 2016a; Chen et al., 2021; Isaacs-Ten et al., 2022; Jia et al., 2021). This evidence concerns the gene SIRT1 and cholestasis.