Similarly, HERV-H LTR-associating 2 (HHLA2), a molecule that is frequently expressed in various tumors including ccRCC, could mediate immune evasion through binding the inhibitory receptor killer cell immunoglobulin-like receptor, three immunoglobulin domains, and long cytoplasmic tail 3 (KIR3DL3) on the NK cells (Bhatt et al., 2021). The gene discussed is HHLA2; the disease is nonpapillary renal cell carcinoma.