M2 states that if there are more than five MVIs, or the MVIs are more than one centimeter from the primary tumor, the tumor is more adhesive, infiltrative and also able to breach tissues surrounding it (34).Previous studies have identified vascular endothelial growth factor A (VEGF-A) and stathmin 1 (STMN1) as biomarkers associated with different grades of MVI. Here, VEGFA is linked to neoplasm.