MAPT and Cognitive impairment: Such rationale may align with findings that amyloid-beta deposition is not well-correlated with cognitive impairment in older adults, and that other abnormalities known to be more strongly correlated with cognitive changes may be the reason for cognitive impairment instead, such as tau pathologies (Villemagne et al., 2013; Jack et al., 2014; Jansen et al., 2015; Bejanin et al., 2017; Brookmeyer and Abdalla, 2018; Ramanan et al., 2021).