APOE and early-onset autosomal dominant Alzheimer disease: At present, this includes Apolipoprotein E4 (APOE4), a well-established gene polymorphism that increases risk for Alzheimer’s Disease (AD) and has been associated with cognitive impairments (Reitz and Mayeux, 2010; Collins and Williams-Gray, 2016; Fernández et al., 2021; Fernández-Calle et al., 2022).