This includes enhancing the presence of neurofibrillary tangles, which is primarily composed of hyperphosphorylated tau protein and is one of the other hallmarks of AD protein pathology (Theendakara et al., 2018; Hunsberger et al., 2019; Husain et al., 2021; Raulin et al., 2022; Pires and Rego, 2023). The gene discussed is MAPT; the disease is Alzheimer disease.