APOE and Parkinson disease: Yet, analysis of these changes and their association with APOE4 in PD is inconsistent, and are limited (Apostolova et al., 2012; Gomperts et al., 2012, 2013; Beyer et al., 2013; Campbell et al., 2013; Nicoletti et al., 2016; Mashima et al., 2017; Rane et al., 2018; Sampedro et al., 2019).