APOE and Alzheimer disease: Other mechanisms thought to be associated with APOE4 in AD are neuroinflammation, mitochondrial deregulation, synaptic deficits, reduced vascular integrity as well as impaired glucose metabolism and autophagy (Theendakara et al., 2018; Hunsberger et al., 2019; Yamazaki et al., 2019; Husain et al., 2021; Serrano-Pozo et al., 2021; Martens et al., 2022; Raulin et al., 2022; Pires and Rego, 2023).