This is supported with preclinical studies using alpha-synuclein mice models, which examined that those expressing the allele developed the most burden of alpha-synuclein pathology, as well as greater and faster cognitive impairment, including memory dysfunction, when compared to those with APOE2 and APOE3 (Davis et al., 2020; Zhao et al., 2020). The gene discussed is SNCA; the disease is Cognitive impairment.