APOE and hypertensive disorder: Moreover, after adjusting both for the prespecified predictors and variables with p < 0.1 in the univariable analysis, including age, sex, hypertension, ICH volume, IVH, and time to CT, the presence of APOE ε4 (OR 2.114, 95% CI 1.038–4.307, p = 0.039), but not the presence of APOE ε2 (OR 0.608, 95% CI 0.252–1.467, p = 0.268), was associated with the island sign (Table 3).