Moreover, the presence of neither APOE ε4 (OR 1.003, 95% CI 0.275–3.665, p = 0.996) nor APOE ε2 (OR 0.638, 95% CI 0.174–2.338, p = 0.498) was associated with the island sign after adjusting for the prespecified predictors and variables with p < 0.1 in the univariable analysis, including age, sex, hypertension, ICH volume, IVH and time to CT (Table 3). This evidence concerns the gene APOE and Hypertension.