In the multivariable analysis, after adjusting for prespecified predictors, including age, sex, hypertension and time to CT, the presence of neither APOE ε4 (OR 0.673, 95% CI 0.193–2.351, p = 0.535) nor APOE ε2 (OR 0.577, 95% CI 0.166–2.002, p = 0.386) was associated with the island sign (Table 3). This evidence concerns the gene APOE and Hypertension.