AFG3L2 and spinocerebellar ataxia type 28: Mutations in AFG3L2 may lead to a clinical spectrum: dominant variants are associated with late onset spinocerebellar ataxia type 28 (SCA28; MIM: 610246), whereas pathogenic biallelic variants lead to spastic ataxia 5 (SPAX5; MIM: #614487) (Franchino et al., 2023; Tulli et al., 2019).