This study evaluates the clinical value of α-Hydroxybutyrate Dehydrogenase (α-HBDH), Cardiac Troponin I (cTnI), and B-Type Natriuretic Peptide (BNP) in the perioperative diagnosis of heart failure in children with congenital heart disease (CHD). This evidence concerns the gene TNNI3 and congenital heart disease.