ROC curve analysis showed that the areas under the curve (AUC) for diagnosing heart failure using preoperative α-HBDH, cTnI, BNP, α-HBDH combined with BNP, cTnI combined with BNP, and α-HBDH, cTnI combined with BNP were 0.736, 0.873, 0.708, 0.764, 0.883, and 0.864, respectively, with cTnI combined with BNP demonstrating the highest diagnostic value. Here, TNNI3 is linked to heart failure.