Immune cell infiltration analysis using the XCELL algorithm demonstrated that CNIH4 was significantly positively correlated with T cell CD4+ Th2 and common lymphoid progenitor cell infiltration and negatively correlated with microenvironment score, endothelial cells, hematopoietic stem cells, T cell CD4+ central memory, T cell CD4+ naïve, T cell CD8+, and cancer-associated fibroblasts to varying degrees (Figure 5F; Supplementary Figures 10A–I). Here, CD4 is linked to cancer.