TGFB1 and autoimmune disease: Consequently, based on the extensive research in the literature, biological importance, genetic significance, epidemiological data, consistency in study design, clinical relevance, innovation, the necessity of the study, and statistical power, this meta-analysis selected the T869C polymorphism as the focus of this research to explore the role of the TGF-β1 T869C genetic polymorphism in the development of autoimmune diseases, providing a basis for the development of diagnostics and treatments for autoimmune diseases.