CASP1 and Sepsis: While a significant increase in the mean fold-change in intracellular caspase-1 levels in the C19wSepsis (> 4-fold increase, **p=0.0021) and Sepsis Alone cohorts (> 4-fold increase, ****p<0.0001) were observed compared to healthy controls, C19NoSepsis cohort showed no significant change (p>0.05).