A significant increase in the mean fold-change in intracellular caspase-3 levels in C19wSepsis patients compared to healthy controls (> 7-fold increase in C19wSepsis, **p=0.0099) was observed, while a significant decrease was noted in the Sepsis Alone cohort (> 5-fold decrease in Sepsis Alone, *p=0.0112) (Figure 7B; Table 3). Here, CASP3 is linked to Sepsis.