The mean fold-change in the secreted levels of caspase-3 showed a significant increase in three clinical cohorts compared to the control cohort: C19wSepsis (> 2-fold increase, **p=0.0013), C19NoSepsis (> 3-fold increase, ***p=0.0001), and Sepsis Alone (> 4-fold increase, ****p<0.0001). This evidence concerns the gene CASP3 and Sepsis.