SQSTM1 and Sepsis: Furthermore, comparison between the clinical cohorts showed a significant decrease in secreted p62 in C19NoSepsis (> 4-fold decrease, ***p=0.0002) and Sepsis Alone (> 2-fold decrease, *p=0.0373) cohorts compared to C19wSepsis, while secreted p62 levels showed a significant decrease in Sepsis Alone cohort compared to that in C19NoSepsis cohort (> 2-fold decrease, *p=0.0235).