While the secreted caspase-1 was not significantly different from that of p62 (p>0.05) in Sepsis Alone cohort, secreted MLKL was significantly higher than that of caspase-1 (> 6-fold increase, ***p=0.0004) and p62 (> 7-fold increase, ***p=0.0002). This evidence concerns the gene CASP1 and Sepsis.