When we silenced GRP94, the regulatory effects of AB23A on TG levels, cellular steatosis, ERS‐related proteins (p‐PERK/PERK, p‐eIF2α/eIF2α, ATF4), and ERAD‐related proteins (FBXO2, DERL, HSP90α) disappeared. This evidence concerns the gene FBXO2 and steatosis.