Specifically, IKKβ-induced NF-κB activation in enterocytes plays a significant role in tumor initiation during the early stages, while IKK2-mediated NF-κB activity in myeloid cells promotes tumor progression by stimulating the expression of proinflammatory cytokines that act as tumor growth factors (Greten et al., 2004). Here, IKBKB is linked to neoplasm.