ALB and Hypoalbuminemia: However, as shown in a study by Reiss et al. (2016), hypoalbuminemia is altering MTX pharmacokinetics as there is a significant negative correlation between albumin level and MTX clearance time, as patients with albumin level below 3.4 g/dL had median time to MTX clearance of 72 h compared to 96 h of non-hypoalbuminemic patients.