The drug binds to proteins at about 30% (Bailey and Briggs, 2004).Etzel et al. conducted a study to evaluate the pharmacokinetics of gentamicin and tobramycin in patients without pleural effusion (n = 1,049), (mean albumin concentration in this group was 2.8 ± 0.7 g/dL) and with pleural effusion and concomitant hypoalbuminemia (n = 260) (mean albumin concentration 3.2 ± 0.7 g/dL). The gene discussed is ALB; the disease is Pleural effusion.