INS and type 2 diabetes mellitus: This is interesting because HPLC diets are often used in the treatment of type 2 diabetes for their reported ability to lower glucose and increase insulin sensitivity (Seino et al., 1983; Gannon and Nuttall, 2004), suggesting a potential role for the elevated ARA in the blood of individuals fed HPLC diets in the prevention of type 2 diabetes (Das, 2018).