TP53 and cancer: On the other hand, PAX8 staining in P17 was inconclusive, but NGS revealed wild-type TP53. Since virtually all HGSOCs carry TP53 mutations (Vang et al., 2016) and considering the primary tumor of this patient was defined as P53 null upon histologic evaluation at diagnosis (Table 2–P53 histological annotation column), wild-type NGS results most likely implied ascites was cancer cell-free.