Heat shock protein overexpression is reported in many cancers such as gastric, colorectal, cervical, and lung cancers. This crucial chaperone is linked to cancer cell proliferation, metastasis, and invasion. In the malarial parasite, this molecule is known for its role as a co-chaperone, thus identifying and bringing client proteins to hsp70 and hsp90 for folding. It also facilitates the viral protein synthesis and folding. Here, HSPA4 is linked to cancer.