CD8A and hepatocellular carcinoma: The serine- and arginine-rich splicing factor SRSF10 promotes glycolysis in HCC by stabilizing MYB RNA, which in turn increases the expression of glycolysis enzymes GLUT1, HK1 and LDHA, thus leading to lactate accumulation in the TME and histone lactylation in macrophages, and consequentially a reduced infiltration of CD8+ T cells[82].