The hypoxia TME promotes the CCL20- and CXCL-5-associated recruitment of Tregs and cDC2 cells in HCC, and the interaction between Tregs and cDC2 cells inhibits antigen-presenting HLA-DR expression on cDC2 cells and impairs antitumor immunity in HCC[70]. The gene discussed is CCL20; the disease is hepatocellular carcinoma.