Cytokines bind to specific receptors on the cell surface and transmit biological information to target cells to control and regulate fundamental biological processes, such as hematopoiesis, inflammation, immunity, and tumor development.[33] SOCS proteins act as cytokine regulators and function as negative feedback inhibitors of cytokine‐induced signal transduction through the JAK/STAT pathway, with SOCS1 being the most effective member of the family capable of directly inhibiting JAK2.[34] Recent studies have reported more applications for SOCS1 as a regulator of ferroptosis‐related genes. The gene discussed is CISH; the disease is neoplasm.