NIBAN2 and osteoporosis: Previous studies have shown that NIBAN2 serves as an unfavorable prognostic factor in multiple cancers.[6, 20] In addition, NIBAN2 is essential for wound healing[21] and ameliorates myocardial ischemia‒reperfusion injury.[6b] Through integrative analysis of multiple databases, NIBAN2 was identified as the most promising osteogenic gene downregulated in osteoporosis.