To examine the potential therapeutic effect of Niban2 in osteoporosis in vivo, we overexpressed Niban2 by intramedullary transduction in ovariectomized (OVX) mouse femurs.[16] Bone loss was confirmed in the OVX mice without intramedullary transduction compared to the sham mice (Figure S8a,b, Supporting Information). Here, NIBAN2 is linked to osteoporosis.