RUNX2 and cleidocranial dysplasia 1: The mutation of RUNX2 gene targeting Runt domain and its NLS were reported to associated with subcellular localization of the mutant protein and cleidocranial dysplasia, an inherited bone disorder disease.[11, 26] However, AS transcripts of RUNX2 lacking exon 6 (Runx2Δ6) were barely reported and paid little attention on its role in bone biology.[8, 11, 27] Thus, our research unraveled a potential mechanism about NIBAN2 on RUNX2 homeostasis.