BGLAP and osteoporosis: To investigate the in vivo function of NIBAN2 in bone, we generated OB‐lineage specific Niban2 knockout mice by crossing Niban2‐floxed mice with Bglap‐Cre mice (Bglap‐Cre;Niban2flox/flox, hereafter named as CKO).[5] The Bglap‐Cre was chosen based on our mIF since Bglap+ cells exhibited highest expression level of Niban2 and a decreasing tendency during osteoporosis (Figure 1e–h).