Mechanistically, Bcl‐2 is a well‐known repressor of autophagy[24, 54] and a regulator of mitochondrial function.[26, 27, 55] Elevated Bcl‐2 expression has also been linked to increased adiposity and body weight in mice.[56] In this study, Mtch2 knockout mitigated obesity and reduced Bcl‐2 protein levels, suggesting that Bcl‐2 may mediate metabolic benefit of Mtch2 ablation via autophagy. The gene discussed is BCL2; the disease is obesity due to melanocortin 4 receptor deficiency.