Obesity is linked to cognitive decline,[62] and MTCH2 variants have been associated with conditions such as Alzheimer's disease[63] and emotional eating.[43] That MTCH2 may be a critical player in neural cell biology was suggested in a study demonstrating mitochondrial dysfunction and impaired cognitive function in mice deficient in forebrain Mtch2.[40] More work is necessary to elucidate the role of MTCH2 in both obesity and its related neurodegeneration. This evidence concerns the gene MTCH2 and early-onset autosomal dominant Alzheimer disease.