Mechanistically, Bcl‐2 is a well‐known repressor of autophagy[24, 54] and a regulator of mitochondrial function.[26, 27, 55] Elevated Bcl‐2 expression has also been linked to increased adiposity and body weight in mice.[56] In this study, Mtch2 knockout mitigated obesity and reduced Bcl‐2 protein levels, suggesting that Bcl‐2 may mediate metabolic benefit of Mtch2 ablation via autophagy. This evidence concerns the gene MTCH2 and obesity due to melanocortin 4 receptor deficiency.