SPPL3 and colorectal cancer: We also identified the critically prognostic genomic molecular features with our model in the COCC cohort, within the top ten genomic molecular features selected by IG values, we found that the CLDN11, HOXA13, B3GNT6, and SIGIRR genes were reported to be associated with the progression of colorectal cancer.[22, 23, 24, 25, 26, 27, 28] Additionally, we discovered that CLDN11, GOLGA7B, MEDAG, SPART, MAFK, SPPL3, and SCAND1 were significantly associated with the prognosis of colorectal cancer by univariate Cox regression analysis (Figure 4D).