Unlike in p53‐mutant cancer cells, PDCD11 barely affect the C‐MYC level in p53‐WT cells, which might be attributed to the high level of HDM2 induced by WT p53[11] and the likely overlapping binding sites of PDCD11 (1033–1431) with HDM2[11] and C‐MYC (Figure 4; Figures S2C and S6, Supporting Information). Here, MDM2 is linked to cancer.