Overexpression of C‐MYC increased the levels of E2F1, CCNE2, and SKP2, and thus decreased the levels of p27 (Figure 2E) to rescue the arrested cell growth and migration (Figure 2F–I), indicating that PDCD11 elicits the oncogenic phenotypes of p53‐mutant cancer cells through the upregulation of C‐MYC downstream pathways. This evidence concerns the gene TP53 and cancer.