SKP2 and cancer: Unlike the tumor suppressor ARF, which also stabilizes C‐MYC by antagonizing SKP2 but induces EGR1‐dependent apoptosis,[18] PDCD11 does not activate the C‐MYC‐EGR1 axis (Figure S4F, Supporting Information), indicating that PDCD11 acts as a tumor‐promoter rather than an apoptosis‐inducer in p53‐mutant cancer cells.