To verify this, we performed western blot (WB) analyses and found that PDCD11 silencing decreased the protein levels of either C‐MYC or its representative oncogenic targets including E2F1, CCNE2, and SKP2 (Figure 2D), which are essential drivers for tumor growth and metastasis.[19, 20] Therefore, downregulation of SKP2 increased the levels of p27 protein[9a] (Figure 2D), contributing to the G1/S arrest induced by PDCD11 silencing (Figure 1M). Here, E2F1 is linked to neoplasm.