The synergy effect is unparalleled, as demonstrated in the following aspects: 1) the needle penetration plus powered particles to achieve such long‐distance transportation of exomes via micro‐robots to distal MI sites, 2) ESMPs plus exosomes regulating cardiomyocyte metabolism in hypoxic environment on the basis of enhancing the local pH, and 3) VEGF plus exosomes to achieve the 3D reconstruction of the vascular network at the infarction site. Here, VEGFA is linked to myocardial infarction.