Differentiation of intestinal tuft cells may serve an important role in mucosal regeneration, while their depletion may contribute to the malabsorption seen in patients suffering from celiac disease or microvillus inclusion disease (MVID), consistent with our observations in Myosin VB knockout mice, which model MVID phenotypes (Huh et al., 2020; Kaji et al., 2021; Kalashyan et al., 2023). This evidence concerns the gene MYO5B and microvillus inclusion disease.