The genetically predicted plasma protein level increases of BLNK (OR = 1.98, 95% CI: 1.34–2.93, P = 6.6 × 10− 4), CD2AP (OR = 1.22, 95% CI: 1.11–1.35, P = 5.9 × 10− 5), PILRA (OR = 1.08, 95% CI: 1.03–1.14, P = 1.9 × 10− 3), and PILRB (OR = 1.08, 95% CI: 1.04–1.12, P = 1.7 × 10− 4) were associated with higher AD risk. The gene discussed is CD2AP; the disease is Alzheimer disease.