Furthermore, DNMT1 exhibited a negative correlation with miR-34a-5p levels and a positive correlation with FoxM1 expression; and alterations in DNMT1, miR-34a-5p, and FoxM1 expression were associated with HCC recurrence, suggesting that DNMT1/miR-34a-5p/FoxM1 axis is pivotal in HCC and represents an important therapeutic target in HCC. Here, FOXM1 is linked to hepatocellular carcinoma.