CXCR2 and neoplasm: Tumor-derived cytokines, such as G-CSF, and VEGF, promote the expansion and recruitment of immunosuppressive neutrophil subpopulations, while chemokines like CXCL1, CXCL2, and CXCL8 mobilize neutrophils from the bone marrow to the tumor [158], with type I IFNs serving as a negative regulator of CXCR2-mediated neutrophil migration [159].