TNF and neoplasm: Type I IFNs, particularly IFN-β, play a crucial role in inducing anti-tumor polarization of neutrophils, transforming them from a pro-tumor to an anti-tumor phenotype characterized by enhanced tumor cytotoxicity, elevated expression of anti-tumor markers such as MHC1, ICAM1 and TNF-α, potent capacity to stimulate cytotoxic T cells [171, 280].