Neutrophils can also kill tumor cells through direct mechanisms like Fas/FasL interactions [114], the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) [115], neutrophil extracellular traps (NETs) [116], and the release of cytotoxic granules containing neutrophil elastase (NE) [117, 118] and cathepsin G [119]. Here, ELANE is linked to neoplasm.