It is noteworthy to find the critical role of Ythdf2 deficiency in antitumor immunity of macrophages via CD8+ T cell response, since the percentage of CD11b+F4/80+iNOS antitumor macrophages was significantly incremented and the percentage of CD11b+F4/80+Arg1 protumor macrophages was decreased in B16-OVA cells in Ythdf2cKO C57BL/6 mice bearing B16-OVA tumor cells compared to Ythdf2f/f control mice [99]. The gene discussed is NOS2; the disease is neoplasm.