JMJD6 and lung adenocarcinoma: Furthermore, Liang et al. [110] indicated that TIAM promotes osimertinib resistance, and M2-like TAM polarization in lung adenocarcinoma, while Chen et al. [111] demonstrated that Jumonji domain-containing 6 (JMJD6) induced M2 polarization via the STAT3/IL-10 signaling axis in Lewis lung carcinoma and B16F10 melanoma cells.