Another study indicates that berberine primarily exerts therapeutic effects on lung fibrosis associated with COVID-19 pneumonia by regulating cell proliferation, metabolism, and survival via tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), signal transducer and activator of transcription 3 (STAT3), and chemokine (C–C motif) ligand 2 (CCL2) [90]. The gene discussed is TNF; the disease is pulmonary fibrosis.